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_____ his knowledge of the mountainous country, John Smith was appointed as our guide.

   A. In spite of      B. On account of

   C. Regardless of    D. Instead of

 _____ his knowledge of the mountainous country, John Smith was appointed as our guide.

   A. In spite of      B. On account of

   C. Regardless of    D. Instead of

_____ his knowledge of the mountainous country, John Smith was appointed as our guide.

A. In spite of      B. On account of   C. Regardless of   D. In place of

_____ his knowledge of the mountainous country, John Smith was appointed as our guide.

       A. In spite of      B. On account of     C. Regardless of    D. Instead of

 _____ his knowledge of the mountainous country, John Smith was appointed as our guide.
A. In spite of            B. On account of       C. Regardless of      D. In place of