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If we work with a strong will, we can overcome any difficulty, _____ great it is.  

A. what               B. how                  C. however             D. Whatever

If we work with a strong will, we can overcome any difficulty, _____great it is.

A. what          B. how          C. however        D. whatever

If we work with a strong will, we can overcome any difficulty, _____great it is.

A. what          B. how          C. however        D. whatever

If we work with a strong will, we can overcome any difficulty, _______great it is.

A. what 　　 B. how

C. however 　 D. whatever